Interest in subcellular organelle-targeting theranostics is substantially increasing due to the significance of subcellular organelle-targeting drug delivery for maximizing therapeutic effects and minimizing s...
Human mesenchymal stem cells (hMSCs) are, due to their pluripotency, useful sources of cells for stem cell therapy and tissue regeneration. The phenotypes of hMSCs are strongly influenced by their microenviron...
Authors: Hatice O. Ozguldez, Junghwa Cha, Yoonmi Hong, Ilkyoo Koh and Pilnam Kim
Black phosphorus (BP) has emerged as a novel class of nanomaterials owing to its unique optical and electronic properties. BP, a two-dimensional (2D) nanomaterial, is a structure where phosphorenes are stacked...
Authors: Yong Cheol Shin, Su-Jin Song, Yu Bin Lee, Moon Sung Kang, Hyun Uk Lee, Jin-Woo Oh and Dong-Wook Han
Mucoadhesive polymers, which may increase the contact time between the polymer and the tissue, have been widely investigated for pharmaceutical formulations. In this study, we developed a new polysaccharide-ba...
Authors: Ik Sung Cho, Hye Min Oh, Myeong Ok Cho, Bo Seul Jang, Jung-Kyo Cho, Kyoung Hwan Park, Sun-Woong Kang and Kang Moo Huh
Photodynamic therapy (PDT) is photo-treatment of malignant or benign diseases using photosensitizing agents, light, and oxygen which generates cytotoxic reactive oxygens and induces tumour regressions. Several...
Authors: Rengarajan Baskaran, Junghan Lee and Su-Geun Yang
Recently, cancer immunotherapy has become standard for cancer treatment. Immunotherapy not only treats primary tumors, but also prevents metastasis and recurrence, representing a major advantage over conventio...
Authors: Wooram Park, Young-Jae Heo and Dong Keun Han
The main purpose of drug delivery systems is to deliver the drugs at the appropriate concentration to the precise target site. Recently, the application of a thin film in the field of drug delivery has gained ...
Authors: Sohyeon Park, Uiyoung Han, Daheui Choi and Jinkee Hong
Cell behavior is the key to tissue regeneration. Given the fact that most of the cells used in tissue engineering are anchorage-dependent, their behavior including adhesion, growth, migration, matrix synthesis...
Authors: Ibrahim Fatih Cengiz, Joaquim Miguel Oliveira and Rui L. Reis
Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and canc...
The chondrogenic differentiation of mesenchymal stem cells (MSCs) is regulated by many factors, including oxygen tensions, growth factors, and cytokines. Evidences have suggested that low oxygen tension seems ...
Authors: Hyun Cheol Bae, Hee Jung Park, Sun Young Wang, Ha Ru Yang, Myung Chul Lee and Hyuk-Soo Han
Biogenic fabrication of silver nanoparticles from naturally occurring biomaterials provides an alternative, eco-friendly and cost-effective means of obtaining nanoparticles. It is a favourite pursuit of all sc...
Authors: Khwaja Salahuddin Siddiqi, M. Rashid, A. Rahman, Tajuddin, Azamal Husen and Sumbul Rehman
Cancer is one of the deadliest threats to human health. Abnormal physiochemical conditions and dysregulated biosynthetic intermediates in the tumor microenvironment (TME) play a significant role in modulating ...
Authors: Saji Uthaman, Kang Moo Huh and In-Kyu Park
Antigen-specific cytotoxic T lymphocytes (CTLs), which eliminate target cells bearing antigenic peptides presented by surface major histocompatibility complex (MHC) class I molecules, play a key role in cancer...
Authors: Jung Min Shin, Seok Ho Song, N. Vijayakameswara Rao, Eun Sook Lee, Hyewon Ko and Jae Hyung Park
Magnetic resonance imaging is one of the diagnostic tools that uses magnetic particles as contrast agents. It is noninvasive methodology which provides excellent spatial resolution. Although magnetic resonance...
Diabetes mellitus (DM) is a chronic progressive metabolic disease that involves uncontrolled elevation of blood glucose levels. Among various therapeutic approaches, GLP-1 prevents type 2 diabetes mellitus (T2...
Authors: Seungbin Cha, Sun Hwa Lee, Sung Hun Kang, Mohammad Nazmul Hasan, Young Jun Kim, Sungpil Cho and Yong-Kyu Lee
Gallstones have conventionally been classified by gross inspection into 4 categories: cholesterol gallstones, black pigment (calcium bilirubinate) gallstones, brown gallstones, and mixed gallstones that contai...
Gadolinium-based contrast agents are widely used as a contrast agent for magnetic resonance imaging. Since gadolinium ions are toxic, many chelators are developed to bind gadolinium ions to prevent free gadoli...
Electrospun fibrous matrices are of great importance for tissue engineering and drug delivery device. However, relatively low mechanical strength of the fibrous matrix is one of the major disadvantages. NDs wi...
Authors: Guk Young Ahn, Tae-Kyung Ryu, Yu Ri Choi, Ju Ri Park, Min Jeong Lee and Sung-Wook Choi
This article [1] has been retracted by the authors due to lack of permission to use and publish the data reported. All authors agree to this retraction.
Authors: Sarath Chandra Veerla, Da Reum Kim and Sung Yun Yang
Citation:Biomaterials Research
2018
22:15
Published on: 18 May 2018
The
original article was published in Biomaterials Research
2018
22:7
Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect. Although several groups have studied directed migration of Schwann...
Authors: Elisabeth B. Evans, Samantha W. Brady, Anubhav Tripathi and Diane Hoffman-Kim
Formation of mature and functional articular cartilage is still challenging in cartilage tissue engineering. This study investigates the potential of using heparin-grafted decellularized extracellular matrix (...
Authors: Yong Kwan Noh, Ping Du, Avelino Dos Santos Da Costa and Kwideok Park
Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparti...
Authors: Gawon Yi, Jihwan Son, Jihye Yoo, Changhee Park and Heebeom Koo
The worldwide demand for the organ replacement or tissue regeneration is increasing steadily. The advancements in tissue engineering and regenerative medicine have made it possible to regenerate such damaged o...
In the past decade, stem cells, with their ability to differentiate into various types of cells, have been proven to be resourceful in regenerative medicine and tissue engineering. Despite the ability to repai...
Authors: Ee-Seul Kang, Da-Seul Kim, Intan Rosalina Suhito, Wanhee Lee, Inbeom Song and Tae-Hyung Kim
Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is rec...
Authors: Yunsup Lee, Jaehoon Choi and Nathaniel S. Hwang
The purpose of this paper is to provide technology trends and information regarding market and prospects in stents used for human blood vessels in Korea and the world.
Authors: Jeong Hee Lee, Eung Do Kim, Eun Jung Jun, Hyoung Sun Yoo and Joon Woo Lee
Controlled drug delivery system is highly important for not only
prolonged the efficacy of drug but also cellular development for tissue
engineering. A number of biopoly...
Authors: Sarath Chandra Veerla, Da Reum Kim and Sung Yun Yang
Fetal bovine serum (FBS) is the most essential supplement in culture media for cellular proliferation, metabolism, and differentiation. However, due to a limited supply and subsequently rising prices, a series...
Biomaterials that promote the self-renewal ability and differentiation capacity of neural stem cells (NSCs) are desirable for improving stem cell therapy to treat neurodegenerative diseases. Incorporation of m...
Authors: Jung Seung Lee, Kisuk Yang, Ann-Na Cho and Seung-Woo Cho
The extracellular matrix (ECM) can directly or indirectly influence on regulation of cell functions such as cell adhesion, migration, proliferation and differentiation. The cell derived ECM (CD-ECM) is a usefu...
Zwitterionic molecules have been widely studied as coating materials for preparing anti-fouling surfaces because they possess strong hydration properties that can resist non-specific protein adsorption. Numero...
Authors: Se Yeong Lee, Yunki Lee, Phuong Le Thi, Dong Hwan Oh and Ki Dong Park
The molecular diagnostics market can be broadly divided into PCR (rt-PCR, d-PCR), NGS(Next Generation Sequencing), Microarray, FISH(Fluorescent in situ-hybridization) and other categories, based on the diagnos...
Authors: Ju Hwan Seo, Joon Woo Lee and Daemyeong Cho
Tissue engineering is an interdisciplinary field that attempts to restore or regenerate tissues and organs through biomimetic fabrication of scaffolds with specific functionality. In recent years, graphene oxi...
Authors: Jiyong Kim, Hwan D. Kim, Jungha Park, Eun-seo Lee, Eugene Kim, Seunghun S. Lee, Jin-Kyung Yang, Yoon-Sik Lee and Nathaniel S. Hwang
During pulmonary artery catheter (PAC) implantation, inaccurate measurements of hemodynamic parameters due to infection or thrombosis of PAC can result in severe complications.
Authors: Jung Wook Han, Yeon Soo Shin, Jung Ju Kim and Ho Sung Son
An electrically conductive hydrogel has emerged to regulate cellular secretion activities with electrical stimulation. However, the electrical conductivity of typical hydrogel systems decreases with increasing...
Authors: Ross J. DeVolder, Yongbeom Seo and Hyunjoon Kong
Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the s...
Authors: Sebastião van Uden, Joana Silva-Correia, Joaquim Miguel Oliveira and Rui Luís Reis
The three-dimensional (3D) system is one of the important factors to engineer a biocompatible and functional scaffold for the applications of cell-based therapies for cartilage repair. The 3D alginate hydrogel...
Authors: Y. W. Ewa-Choy, B. Pingguan-Murphy, N. A. Abdul-Ghani, J. Jahendran and K. H. Chua
Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling act...
Authors: Trang Huyen Le Kim, Hwiseok Jun, Jin Ho Kim, Keunchil Park, Jee Seon Kim and Yoon Sung Nam
Gold nanoclusters (AuNCs) are typically composed of several to tens of gold atoms which are stabilized with biomacromolecules such as bovine serum albumin (BSA). Au NCs fluoresces in the visible to near infrar...
Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone...
Authors: Markus Göttlicher, Marcus Rohnke, Yannik Moryson, Jürgen Thomas, Joachim Sann, Anja Lode, Matthias Schumacher, Romy Schmidt, Stefan Pilz, Annett Gebert, Thomas Gemming and Jürgen Janek
In biomedicine, adhesives for hard and soft tissues are crucial for various clinical purposes. However, compared with that under dry conditions, adhesion performance in the presence of water or moisture is dra...
Authors: Kyu Ha Park, Keum-Yong Seong, Seung Yun Yang and Sungbaek Seo
The injection of botulinum toxin (BTX) to reduce facial wrinkles is one of the most frequently performed plastic surgery procedures. The biocompatible hydrogels are injected with BTX for effective tissue augme...
Authors: Ki Su Kim, Yun Seop Kim, Kai Bao, Hideyuki Wada, Hak Soo Choi and Sei Kwang Hahn
Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional funct...
Crosslinked gelatin nanofibers are one of the widely used scaffolds for soft tissue engineering. However, modifying the biodegradation rate of chemically crosslinked gelatin is necessary to facilitate cell mig...
Authors: Jae Baek Lee, Young-Gwang Ko, Donghwan Cho, Won Ho Park and Oh Hyeong Kwon
Calcium phosphate (CaP) based nanoparticles are considered to be ideal drug carriers for delivery of anticancer drugs because of their excellent biocompatibility and pH responsiveness. However, CaP nanoparticl...
In this study, silk fibroin (SF) composite hydrogels containing hydroxyapatite (HAP) nanoparticles (NPs) for bone tissue engineering were fabricated using gamma-ray (γ-ray) irradiation treatment. During the ir...
Authors: Min Hee Kim, Beom Su Kim, Jun Lee, Donghwan Cho, Oh Hyeong Kwon and Won Ho Park
To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen–hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coat...
Authors: Gi-Wan Kwon, Kailash Chandra Gupta, Kyung-Hye Jung and Inn-Kyu Kang
In vitro cell testing of degradable bioceramics such as brushite or monetite is often challenging due to the ion release into or adsorption from the culture medium. These ionic changes...
Authors: Martha Schamel, Jake E. Barralet, Jürgen Groll and Uwe Gbureck
Periodontal disease is categorized by the destruction of periodontal tissues. Over the years, there have been several clinical techniques and material options that been investigated for periodontal defect repa...
Authors: Zeeshan Sheikh, Nader Hamdan, Yuichi Ikeda, Marc Grynpas, Bernhard Ganss and Michael Glogauer
Calcium sulphate (CS) has been used in bone grafting since the 1800s. It has not replaced autograft as the gold standard, however, since its dissolution occurs rapidly in bodily fluids, meaning that the materi...
