An electrically conductive hydrogel has emerged to regulate cellular secretion activities with electrical stimulation. However, the electrical conductivity of typical hydrogel systems decreases with increasing...
Authors: Ross J. DeVolder, Yongbeom Seo and Hyunjoon Kong
Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the s...
Authors: Sebastião van Uden, Joana Silva-Correia, Joaquim Miguel Oliveira and Rui Luís Reis
Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling act...
Authors: Trang Huyen Le Kim, Hwiseok Jun, Jin Ho Kim, Keunchil Park, Jee Seon Kim and Yoon Sung Nam
Gold nanoclusters (AuNCs) are typically composed of several to tens of gold atoms which are stabilized with biomacromolecules such as bovine serum albumin (BSA). Au NCs fluoresces in the visible to near infrar...
The three-dimensional (3D) system is one of the important factors to engineer a biocompatible and functional scaffold for the applications of cell-based therapies for cartilage repair. The 3D alginate hydrogel...
Authors: Y. W. Ewa-Choy, B. Pingguan-Murphy, N. A. Abdul-Ghani, J. Jahendran and K. H. Chua
Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone...
Authors: Markus Göttlicher, Marcus Rohnke, Yannik Moryson, Jürgen Thomas, Joachim Sann, Anja Lode, Matthias Schumacher, Romy Schmidt, Stefan Pilz, Annett Gebert, Thomas Gemming and Jürgen Janek
Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional funct...
In biomedicine, adhesives for hard and soft tissues are crucial for various clinical purposes. However, compared with that under dry conditions, adhesion performance in the presence of water or moisture is dra...
Authors: Kyu Ha Park, Keum-Yong Seong, Seung Yun Yang and Sungbaek Seo
The injection of botulinum toxin (BTX) to reduce facial wrinkles is one of the most frequently performed plastic surgery procedures. The biocompatible hydrogels are injected with BTX for effective tissue augme...
Authors: Ki Su Kim, Yun Seop Kim, Kai Bao, Hideyuki Wada, Hak Soo Choi and Sei Kwang Hahn
Crosslinked gelatin nanofibers are one of the widely used scaffolds for soft tissue engineering. However, modifying the biodegradation rate of chemically crosslinked gelatin is necessary to facilitate cell mig...
Authors: Jae Baek Lee, Young-Gwang Ko, Donghwan Cho, Won Ho Park and Oh Hyeong Kwon
Calcium phosphate (CaP) based nanoparticles are considered to be ideal drug carriers for delivery of anticancer drugs because of their excellent biocompatibility and pH responsiveness. However, CaP nanoparticl...
In this study, silk fibroin (SF) composite hydrogels containing hydroxyapatite (HAP) nanoparticles (NPs) for bone tissue engineering were fabricated using gamma-ray (γ-ray) irradiation treatment. During the ir...
Authors: Min Hee Kim, Beom Su Kim, Jun Lee, Donghwan Cho, Oh Hyeong Kwon and Won Ho Park
To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen–hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coat...
Authors: Gi-Wan Kwon, Kailash Chandra Gupta, Kyung-Hye Jung and Inn-Kyu Kang
In vitro cell testing of degradable bioceramics such as brushite or monetite is often challenging due to the ion release into or adsorption from the culture medium. These ionic changes...
Authors: Martha Schamel, Jake E. Barralet, Jürgen Groll and Uwe Gbureck
Periodontal disease is categorized by the destruction of periodontal tissues. Over the years, there have been several clinical techniques and material options that been investigated for periodontal defect repa...
Authors: Zeeshan Sheikh, Nader Hamdan, Yuichi Ikeda, Marc Grynpas, Bernhard Ganss and Michael Glogauer
The objective of this study was to investigate the in vivo effect of bioactive composites with poly(lactic acid) (PLA) or polycaprolactone (PCL) as the matrix, reinforced with bioplastic flax fibers, on the su...
Authors: Tomasz Gredes, Sandra Schönitz, Tomasz Gedrange, Lukas Stepien, Karol Kozak and Christiane Kunert-Keil
Calcium sulphate (CS) has been used in bone grafting since the 1800s. It has not replaced autograft as the gold standard, however, since its dissolution occurs rapidly in bodily fluids, meaning that the materi...
This study aimed to evaluate the anti-aging effect of a newly prepared insect-derived compound, dung beetle glycosaminoglycan (GAG), given intraperitoneally to old SD rats as part of their diet for 1 month. In...
Authors: Mi Young Ahn, Ban Ji Kim, Ha Jeong Kim, Jae Sam Hwang, Yi-Sook Jung and Kun-Koo Park
Bioinorganics have been explored as additives to ceramic bone graft substitutes with the aim to improve their performance in repair and regeneration of large bone defects. Silicon (Si), an essential trace elem...
Authors: Ana I. Rodrigues, Rui L. Reis, Clemens A. van Blitterswijk, Isabel B. Leonor and Pamela Habibović
Dexamethasone (DEX) is used for the treatment of various inner ear diseases. However, the molecular mechanism of DEX on gentamicin induced hair cell damage is not known. Therefore, this study investigated the ...
Authors: Jin Ho Lee, Se Heang Oh, Tae Ho Kim, Yoon Young Go and Jae-Jun Song
The topographical cue is major influence on skeletal muscle cell culture because the structure is highly organized and consists of long parallel bundles of multinucleated myotubes that are formed by differenti...
Authors: Sung Ho Cha, Hyun Jong Lee and Won-Gun Koh
Direct reprogramming which changes the fate of matured cell is a very useful technique with a great interest recently. This approach can eliminate the drawbacks of direct usage of stem cells and allow the pati...
Intestinal lymphatic drug delivery has been widely studied because drugs can bypass the first-pass metabolism in the liver via the lymphatic route, which increases oral bioavailability. Various lipid-based nan...
In this study, cytotoxicity of various novel poly(alkylpehnol) derivatives which, one of constituent for vulcanizing agent, could be adjusted in medical elastic rubber applications were investigated under vari...
Authors: Joon Woo Chon, Ji Yun Lee, Yoon Ju Song, Jin Hwan Kim and Dong June Chung
Mechanical properties and cyto-compatibility of a composite scaffold which possessed negative (−) Poisson’s ratio (NPR) was investigated for effective load transfer from auxetic scaffold to cell.
Authors: Hong Jin Choi, Jun Jae Lee, Jung Bok Lee, Hak-Joon Sung, Jung-Woog Shin, Ji Won Shin, Yanru Wu and Jeong Koo Kim
The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, an...
Authors: Rajendran JC Bose, Soo-Hong Lee and Hansoo Park
Auxetic scaffolds (experimental) was fabricated by using poly(D, L-lactic-co-glycolic acid), 50:50, (PLGA) for effective bone cell proliferation with mechanical stimulation.
Authors: Hong Jin Choi, Jun Jae Lee, Yeong Jun Park, Jung-Woog Shin, Hak-Joon Sung, Ji Won Shin, Yanru Wu and Jeong Koo Kim
Dityrosine crosslinking in proteins is a bioinspired method of forming hydrogels. This study compares oxidative enzyme initiators for their relative crosslinking efficiency and cytocompatibility using the same...
Authors: Justine J. Roberts, Pratibha Naudiyal, Khoon S. Lim, Laura A. Poole-Warren and Penny J. Martens
Hydrogels that possess hydrophilic and soft characteristics have been widely used in various biomedical applications, such as tissue engineering scaffolds and drug delivery. Conventional hydrogels are not elec...
Authors: Jongcheol Yang, Goeun Choe, Sumi Yang, Hyerim Jo and Jae Young Lee
Cell penetrating peptides (CPPs) as one class of non-viral vectors, have been widely explored as a delivery tool due to their cell-penetrating capability with low cytotoxicity. However, CPPs have reported to h...
Authors: Chanuk Jeong, Jisang Yoo, DaeYong Lee and Yeu-Chun Kim
Hyaluronic acid (HA) dermal biphasic fillers are synthesized for their efficacy in correcting aesthetic defects such as wrinkles, scars and facial contouring defects. The fillers consist of crosslinked HA micr...
Authors: Cheolbyong Chun, Deuk Yong Lee, Jin-Tae Kim, Mi-Kyung Kwon, Young-Zu Kim and Seok-Soon Kim
Solid organ fabrication is an ultimate goal of Regenerative Medicine. Since the introduction of Tissue Engineering in 1993, functional biomaterials, stem cells, tunable microenvironments, and high-resolution i...
Authors: Jangwook P. Jung, Didarul B. Bhuiyan and Brenda M. Ogle
The aim of this study is to investigate the physicochemical and structural properties of Medifoam®Silver and to compare with other commercially available silver-containing polyurethane (PU) foam dressing in vi...
Authors: Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller, Harsha Arumugam and Young-IL Jeong
Bio-products from stem/progenitor cells, such as extracellular vesicles, are likely a new promising approach for reprogramming resident cells in both acute and chronic kidney disease. Forty CKD patients stage ...
Authors: Wael Nassar, Mervat El-Ansary, Dina Sabry, Mostafa A. Mostafa, Tarek Fayad, Esam Kotb, Mahmoud Temraz, Abdel-Naser Saad, Wael Essa and Heba Adel
Various micropatterned surfaces capable of guiding the selective adhesion of biomolecules such as proteins and cells are of great interests in biosensor, diagnostics, drug screening, and tissue engineering. In...
Authors: Jungmok You, June Seok Heo, Hyun Ok Kim and Eunkyoung Kim
Controlling the fate of mesenchymal stems cells (MSCs) including proliferation, migration and differentiation has recently been studied by many researchers in the tissue engineering field. Especially, recruitm...
Authors: Dayoung Yoon, Hyerim Kim, Eojin Lee, Min Hee Park, Seok Chung, Hojeong Jeon, Cheol-Hee Ahn and Kangwon Lee
After tumor resection, bone reconstruction such as skull base reconstruction using interconnected porous structure is absolutely necessary. In this study, porous scaffolds for bone reconstruction were prepared...
Authors: Chang-Shik Kim, Kyung-Hye Jung, Hun Kim, Chan-Bong Kim and Inn-Kyu Kang
The cellulose membrane (CM) is a major component of plant cell walls and is both a chemically and mechanically stable synthetic polymer with many applications for use in tissue engineering. However, due to its...
Authors: Mi Young Eo, Huan Fan, Yun Ju Cho, Soung Min Kim and Suk Keun Lee
Antibacterial coatings of medical devices have been introduced as a promising approach to reduce the risk of infection. In this context, diamond-like carbon coated polyethylene (DLC-PE) can be enriched with ba...
Authors: Norbert Harrasser, Sebastian Jüssen, Andreas Obermeir, Ralf Kmeth, Bernd Stritzker, Hans Gollwitzer and Rainer Burgkart
T cells play a central role in immune-homeostasis; specifically in the induction of antigen-specific adaptive immunity against pathogens and mutated self with immunological memory. The thymus is the unique org...
Immunodeficient mouse models that accept human cell and tissue grafts can contribute greater knowledge to human stem cell research. In this technical report, we used biomaterial implants seeded with geneticall...
Authors: Jungwoo Lee, Dirk Heckl and Biju Parekkadan
Contamination of biomedical devices in a biological medium, biofouling, is a major cause of infection and is entirely avoidable. This mini-review will coherently present the broad range of antifouling strategi...
Authors: Vinod B. Damodaran and N. Sanjeeva Murthy
We investigated the physicochemical properties of Medifoam® N and its wound healing performance compared to other commercially available polyurethane (PU) foam dressing in vitro and in vivo to gain insight in ...
Authors: Seung Moon Lee, Il Kyu Park, Yong Soo Kim, Hyun Jung Kim, Hanlim Moon, Stefan Mueller and Young-IL Jeong
Regenerative endodontics has been proposed to replace damaged and underdeveloped tooth structures with normal pulp-dentin tissue by providing a natural extracellular matrix (ECM) mimicking environment; stem ce...
Authors: Sagar N. Kaushik, Bogeun Kim, Alexander M. Cruz Walma, Sung Chul Choi, Hui Wu, Jeremy J. Mao, Ho-Wook Jun and Kyounga Cheon
Cardiac fibrosis occurs naturally after myocardial infarction. While the initially formed fibrotic tissue prevents the infarcted heart tissue from rupture, the progression of cardiac fibrosis continuously expa...
