Articles

Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer

Mucoadhesive polymers, which may increase the contact time between the polymer and the tissue, have been widely investigated for pharmaceutical formulations. In this study, we developed a new polysaccharide-ba...

Authors: Ik Sung Cho, Hye Min Oh, Myeong Ok Cho, Bo Seul Jang, Jung-Kyo Cho, Kyoung Hwan Park, Sun-Woong Kang and Kang Moo Huh

Layer-by-layer assembled polymeric thin films as prospective drug delivery carriers: design and applications

The main purpose of drug delivery systems is to deliver the drugs at the appropriate concentration to the precise target site. Recently, the application of a thin film in the field of drug delivery has gained ...

Authors: Sohyeon Park, Uiyoung Han, Daheui Choi and Jinkee Hong

Injectable hydrogels delivering therapeutic agents for disease treatment and tissue engineering

Injectable hydrogels have been extensively researched for the use as scaffolds or as carriers of therapeutic agents such as drugs, cells, proteins, and bioactive molecules in the treatment of diseases and canc...

Authors: Jin Hyun Lee

Micro-CT – a digital 3D microstructural voyage into scaffolds: a systematic review of the reported methods and results

Cell behavior is the key to tissue regeneration. Given the fact that most of the cells used in tissue engineering are anchorage-dependent, their behavior including adhesion, growth, migration, matrix synthesis...

Authors: Ibrahim Fatih Cengiz, Joaquim Miguel Oliveira and Rui L. Reis

Clinical development of photodynamic agents and therapeutic applications

Photodynamic therapy (PDT) is photo-treatment of malignant or benign diseases using photosensitizing agents, light, and oxygen which generates cytotoxic reactive oxygens and induces tumour regressions. Several...

Authors: Rengarajan Baskaran, Junghan Lee and Su-Geun Yang

New opportunities for nanoparticles in cancer immunotherapy

Recently, cancer immunotherapy has become standard for cancer treatment. Immunotherapy not only treats primary tumors, but also prevents metastasis and recurrence, representing a major advantage over conventio...

Authors: Wooram Park, Young-Jae Heo and Dong Keun Han

Biogenic fabrication and characterization of silver nanoparticles using aqueous-ethanolic extract of lichen (Usnea longissima) and their antimicrobial activity

Biogenic fabrication of silver nanoparticles from naturally occurring biomaterials provides an alternative, eco-friendly and cost-effective means of obtaining nanoparticles. It is a favourite pursuit of all sc...

Authors: Khwaja Salahuddin Siddiqi, M. Rashid, A. Rahman, Tajuddin, Azamal Husen and Sumbul Rehman

Tumor microenvironment-responsive nanoparticles for cancer theragnostic applications

Cancer is one of the deadliest threats to human health. Abnormal physiochemical conditions and dysregulated biosynthetic intermediates in the tumor microenvironment (TME) play a significant role in modulating ...

Authors: Saji Uthaman, Kang Moo Huh and In-Kyu Park

A carboxymethyl dextran-based polymeric conjugate as the antigen carrier for cancer immunotherapy

Antigen-specific cytotoxic T lymphocytes (CTLs), which eliminate target cells bearing antigenic peptides presented by surface major histocompatibility complex (MHC) class I molecules, play a key role in cancer...

Authors: Jung Min Shin, Seok Ho Song, N. Vijayakameswara Rao, Eun Sook Lee, Hyewon Ko and Jae Hyung Park

Theranostics and contrast agents for magnetic resonance imaging

Magnetic resonance imaging is one of the diagnostic tools that uses magnetic particles as contrast agents. It is noninvasive methodology which provides excellent spatial resolution. Although magnetic resonance...

Authors: Yohan Jeong, Hee Sook Hwang and Kun Na

Antibody-mediated oral delivery of therapeutic DNA for type 2 diabetes mellitus

Diabetes mellitus (DM) is a chronic progressive metabolic disease that involves uncontrolled elevation of blood glucose levels. Among various therapeutic approaches, GLP-1 prevents type 2 diabetes mellitus (T2...

Authors: Seungbin Cha, Sun Hwa Lee, Sung Hun Kang, Mohammad Nazmul Hasan, Young Jun Kim, Sungpil Cho and Yong-Kyu Lee

Classification of gallstones using Fourier-transform infrared spectroscopy and photography

Gallstones have conventionally been classified by gross inspection into 4 categories: cholesterol gallstones, black pigment (calcium bilirubinate) gallstones, brown gallstones, and mixed gallstones that contai...

Authors: Byeong Jo Ha and Sangsoo Park

Synthesis of a gadolinium based-macrocyclic MRI contrast agent for effective cancer diagnosis

Gadolinium-based contrast agents are widely used as a contrast agent for magnetic resonance imaging. Since gadolinium ions are toxic, many chelators are developed to bind gadolinium ions to prevent free gadoli...

Authors: Yohan Jeong and Kun Na

Fabrication and optimization of Nanodiamonds-composited poly(ε-caprolactone) fibrous matrices for potential regeneration of hard tissues

Electrospun fibrous matrices are of great importance for tissue engineering and drug delivery device. However, relatively low mechanical strength of the fibrous matrix is one of the major disadvantages. NDs wi...

Authors: Guk Young Ahn, Tae-Kyung Ryu, Yu Ri Choi, Ju Ri Park, Min Jeong Lee and Sung-Wook Choi

Retraction Note: Fabrication of a microfluidic device for studying the in situ drug-loading/release behavior of graphene oxide-encapsulated hydrogel beads

This article [1] has been retracted by the authors due to lack of permission to use and publish the data reported. All authors agree to this retraction.

Authors: Sarath Chandra Veerla, Da Reum Kim and Sung Yun Yang

Schwann cell durotaxis can be guided by physiologically relevant stiffness gradients

Successful nerve regeneration depends upon directed migration of morphologically specialized repair state Schwann cells across a nerve defect. Although several groups have studied directed migration of Schwann...

Authors: Elisabeth B. Evans, Samantha W. Brady, Anubhav Tripathi and Diane Hoffman-Kim

Induction of chondrogenesis of human placenta-derived mesenchymal stem cells via heparin-grafted human fibroblast derived matrix

Formation of mature and functional articular cartilage is still challenging in cartilage tissue engineering. This study investigates the potential of using heparin-grafted decellularized extracellular matrix (...

Authors: Yong Kwan Noh, Ping Du, Avelino Dos Santos Da Costa and Kwideok Park

Application of click chemistry in nanoparticle modification and its targeted delivery

Click chemistry is termed as a group of chemical reactions with favorable reaction rate and orthogonality. Recently, click chemistry is paving the way for novel innovations in biomedical science, and nanoparti...

Authors: Gawon Yi, Jihwan Son, Jihye Yoo, Changhee Park and Heebeom Koo

Recent trends in bioinks for 3D printing

The worldwide demand for the organ replacement or tissue regeneration is increasing steadily. The advancements in tissue engineering and regenerative medicine have made it possible to regenerate such damaged o...

Authors: Janarthanan Gopinathan and Insup Noh

Two-dimensional material-based bionano platforms to control mesenchymal stem cell differentiation

In the past decade, stem cells, with their ability to differentiate into various types of cells, have been proven to be resourceful in regenerative medicine and tissue engineering. Despite the ability to repai...

Authors: Ee-Seul Kang, Da-Seul Kim, Intan Rosalina Suhito, Wanhee Lee, Inbeom Song and Tae-Hyung Kim

Regulation of lubricin for functional cartilage tissue regeneration: a review

Lubricin is chondrocyte-secreted glycoprotein that primarily conducts boundary lubrication between joint surfaces. Besides its cytoprotective function and extracellular matrix (ECM) attachment, lubricin is rec...

Authors: Yunsup Lee, Jaehoon Choi and Nathaniel S. Hwang

Analysis of trends and prospects regarding stents for human blood vessels

The purpose of this paper is to provide technology trends and information regarding market and prospects in stents used for human blood vessels in Korea and the world.

Authors: Jeong Hee Lee, Eung Do Kim, Eun Jung Jun, Hyoung Sun Yoo and Joon Woo Lee

RETRACTED ARTICLE: Fabrication of a microfluidic device for studying the in situ drug-loading/release behavior of graphene oxide-encapsulated hydrogel beads

Controlled drug delivery system is highly important for not only prolonged the efficacy of drug but also cellular development for tissue engineering. A number of biopoly...

Authors: Sarath Chandra Veerla, Da Reum Kim and Sung Yun Yang

The effect of serum types on Chondrogenic differentiation of adipose-derived stem cells

Fetal bovine serum (FBS) is the most essential supplement in culture media for cellular proliferation, metabolism, and differentiation. However, due to a limited supply and subsequently rising prices, a series...

Authors: Hyeran Cho, Aeri Lee and Kyobum Kim

Ferritin nanoparticles for improved self-renewal and differentiation of human neural stem cells

Biomaterials that promote the self-renewal ability and differentiation capacity of neural stem cells (NSCs) are desirable for improving stem cell therapy to treat neurodegenerative diseases. Incorporation of m...

Authors: Jung Seung Lee, Kisuk Yang, Ann-Na Cho and Seung-Woo Cho

Differentiated osteoblasts derived decellularized extracellular matrix to promote osteogenic differentiation

The extracellular matrix (ECM) can directly or indirectly influence on regulation of cell functions such as cell adhesion, migration, proliferation and differentiation. The cell derived ECM (CD-ECM) is a usefu...

Authors: Jin Jeon, Min Suk Lee and Hee Seok Yang

Sulfobetaine methacrylate hydrogel-coated anti-fouling surfaces for implantable biomedical devices

Zwitterionic molecules have been widely studied as coating materials for preparing anti-fouling surfaces because they possess strong hydration properties that can resist non-specific protein adsorption. Numero...

Authors: Se Yeong Lee, Yunki Lee, Phuong Le Thi, Dong Hwan Oh and Ki Dong Park

The market trend analysis and prospects of cancer molecular diagnostics kits

The molecular diagnostics market can be broadly divided into PCR (rt-PCR, d-PCR), NGS(Next Generation Sequencing), Microarray, FISH(Fluorescent in situ-hybridization) and other categories, based on the diagnos...

Authors: Ju Hwan Seo, Joon Woo Lee and Daemyeong Cho

Enhanced osteogenic commitment of murine mesenchymal stem cells on graphene oxide substrate

Tissue engineering is an interdisciplinary field that attempts to restore or regenerate tissues and organs through biomimetic fabrication of scaffolds with specific functionality. In recent years, graphene oxi...

Authors: Jiyong Kim, Hwan D. Kim, Jungha Park, Eun-seo Lee, Eugene Kim, Seunghun S. Lee, Jin-Kyung Yang, Yoon-Sik Lee and Nathaniel S. Hwang

Comparison of in vivo antibacterial and antithrombotic activities of two types of pulmonary artery catheters in pig

During pulmonary artery catheter (PAC) implantation, inaccurate measurements of hemodynamic parameters due to infection or thrombosis of PAC can result in severe complications.

Authors: Jung Wook Han, Yeon Soo Shin, Jung Ju Kim and Ho Sung Son

Proangiogenic alginate-g-pyrrole hydrogel with decoupled control of mechanical rigidity and electrically conductivity

An electrically conductive hydrogel has emerged to regulate cellular secretion activities with electrical stimulation. However, the electrical conductivity of typical hydrogel systems decreases with increasing...

Authors: Ross J. DeVolder, Yongbeom Seo and Hyunjoon Kong

Current strategies for treatment of intervertebral disc degeneration: substitution and regeneration possibilities

Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the s...

Authors: Sebastião van Uden, Joana Silva-Correia, Joaquim Miguel Oliveira and Rui Luís Reis

Lipiodol nanoemulsions stabilized with polyglycerol-polycaprolactone block copolymers for theranostic applications

Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling act...

Authors: Trang Huyen Le Kim, Hwiseok Jun, Jin Ho Kim, Keunchil Park, Jee Seon Kim and Yoon Sung Nam

Oligochitosan-stabilized photoluminescent gold nanoconstructs for optical bioimaging

Gold nanoclusters (AuNCs) are typically composed of several to tens of gold atoms which are stabilized with biomacromolecules such as bovine serum albumin (BSA). Au NCs fluoresces in the visible to near infrar...

Authors: Donghyuck Yoo and Dongwon Lee

Effect of alginate concentration on chondrogenesis of co-cultured human adipose-derived stem cells and nasal chondrocytes: a biological study

The three-dimensional (3D) system is one of the important factors to engineer a biocompatible and functional scaffold for the applications of cell-based therapies for cartilage repair. The 3D alginate hydrogel...

Authors: Y. W. Ewa-Choy, B. Pingguan-Murphy, N. A. Abdul-Ghani, J. Jahendran and K. H. Chua

Functionalization of Ti-40Nb implant material with strontium by reactive sputtering

Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone...

Authors: Markus Göttlicher, Marcus Rohnke, Yannik Moryson, Jürgen Thomas, Joachim Sann, Anja Lode, Matthias Schumacher, Romy Schmidt, Stefan Pilz, Annett Gebert, Thomas Gemming and Jürgen Janek

Polyion complex micelle formed from tetraphenylethene containing block copolymer

Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional funct...

Authors: Seong Min Lee and Woo-Dong Jang

Advances in medical adhesives inspired by aquatic organisms’ adhesion

In biomedicine, adhesives for hard and soft tissues are crucial for various clinical purposes. However, compared with that under dry conditions, adhesion performance in the presence of water or moisture is dra...

Authors: Kyu Ha Park, Keum-Yong Seong, Seung Yun Yang and Sungbaek Seo

Bioimaging of botulinum toxin and hyaluronate hydrogels using zwitterionic near-infrared fluorophores

The injection of botulinum toxin (BTX) to reduce facial wrinkles is one of the most frequently performed plastic surgery procedures. The biocompatible hydrogels are injected with BTX for effective tissue augme...

Authors: Ki Su Kim, Yun Seop Kim, Kai Bao, Hideyuki Wada, Hak Soo Choi and Sei Kwang Hahn

Modification and optimization of electrospun gelatin sheets by electron beam irradiation for soft tissue engineering

Crosslinked gelatin nanofibers are one of the widely used scaffolds for soft tissue engineering. However, modifying the biodegradation rate of chemically crosslinked gelatin is necessary to facilitate cell mig...

Authors: Jae Baek Lee, Young-Gwang Ko, Donghwan Cho, Won Ho Park and Oh Hyeong Kwon

Anticancer activity of drug-loaded calcium phosphate nanocomposites against human osteosarcoma

Calcium phosphate (CaP) based nanoparticles are considered to be ideal drug carriers for delivery of anticancer drugs because of their excellent biocompatibility and pH responsiveness. However, CaP nanoparticl...

Authors: Kyoung Dan Son and Young-Jin Kim

Silk fibroin/hydroxyapatite composite hydrogel induced by gamma-ray irradiation for bone tissue engineering

In this study, silk fibroin (SF) composite hydrogels containing hydroxyapatite (HAP) nanoparticles (NPs) for bone tissue engineering were fabricated using gamma-ray (γ-ray) irradiation treatment. During the ir...

Authors: Min Hee Kim, Beom Su Kim, Jun Lee, Donghwan Cho, Oh Hyeong Kwon and Won Ho Park

Lamination of microfibrous PLGA fabric by electrospinning a layer of collagen-hydroxyapatite composite nanofibers for bone tissue engineering

To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen–hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coat...

Authors: Gi-Wan Kwon, Kailash Chandra Gupta, Kyung-Hye Jung and Inn-Kyu Kang

In vitro ion adsorption and cytocompatibility of dicalcium phosphate ceramics

In vitro cell testing of degradable bioceramics such as brushite or monetite is often challenging due to the ion release into or adsorption from the culture medium. These ionic changes...

Authors: Martha Schamel, Jake E. Barralet, Jürgen Groll and Uwe Gbureck

Natural graft tissues and synthetic biomaterials for periodontal and alveolar bone reconstructive applications: a review

Periodontal disease is categorized by the destruction of periodontal tissues. Over the years, there have been several clinical techniques and material options that been investigated for periodontal defect repa...

Authors: Zeeshan Sheikh, Nader Hamdan, Yuichi Ikeda, Marc Grynpas, Bernhard Ganss and Michael Glogauer

In vivo analysis of covering materials composed of biodegradable polymers enriched with flax fibers

The objective of this study was to investigate the in vivo effect of bioactive composites with poly(lactic acid) (PLA) or polycaprolactone (PCL) as the matrix, reinforced with bioplastic flax fibers, on the su...

Authors: Tomasz Gredes, Sandra Schönitz, Tomasz Gedrange, Lukas Stepien, Karol Kozak and Christiane Kunert-Keil

Characterisation of a novel poly (ether ether ketone)/calcium sulphate composite for bone augmentation

Calcium sulphate (CS) has been used in bone grafting since the 1800s. It has not replaced autograft as the gold standard, however, since its dissolution occurs rapidly in bodily fluids, meaning that the materi...

Authors: Erik A. B. Hughes and Liam M. Grover

Anti-aging effect and gene expression profiling of dung beetle glycosaminoglycan in aged rats

This study aimed to evaluate the anti-aging effect of a newly prepared insect-derived compound, dung beetle glycosaminoglycan (GAG), given intraperitoneally to old SD rats as part of their diet for 1 month. In...

Authors: Mi Young Ahn, Ban Ji Kim, Ha Jeong Kim, Jae Sam Hwang, Yi-Sook Jung and Kun-Koo Park

Calcium phosphates and silicon: exploring methods of incorporation

Bioinorganics have been explored as additives to ceramic bone graft substitutes with the aim to improve their performance in repair and regeneration of large bone defects. Silicon (Si), an essential trace elem...

Authors: Ana I. Rodrigues, Rui L. Reis, Clemens A. van Blitterswijk, Isabel B. Leonor and Pamela Habibović

Erratum to: Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

Authors: Wael Nassar, Mervat El-Ansary, Dina Sabry, Mostafa A. Mostafa, Tarek Fayad, Esam Kotb, Mahmoud Temraz, Abdel-Naser Saad, Wael Essa and Heba Adel