Fig. 2

Synergistic hypoxia reversal by oxygen supplied and consumption reduced. a The uptake behavior of the Oxygen Tank by AGS cells in different time points (1 h, 2 h, 4 h, and 8 h) is determined by flow cytometry. b Quantification result of the flow cytometry evaluation. c Schematic illustration of instrument for dissolved oxygen measurement. d Oxygen release curves of different NPs (PBS, RBCm@AIP NPs, and Oxygen Tank). e The dissolved oxygen curves of the culture medium within AGS cells after different treatments (PBS, IP NPs, AIP NPs, and Oxygen Tank). f Confocal fluorescence images of Hif-1α staining of AGS cells after different treatments (PBS in hypoxia condition, IP NPs in hypoxia condition, AIP NPs in hypoxia condition, Oxygen Tank in hypoxia condition, and PBS in normoxia condition). The scale bar is 20 μm