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Fig. 5 | Biomaterials Research

Fig. 5

From: Kidney tissue regeneration using bioactive scaffolds incorporated with differentiating extracellular vesicles and intermediate mesoderm cells

Fig. 5

In vivo evaluations for renal differentiation-related bioactivities. (A) Time schedules for scaffold implantations and in vivo analysis for 3/4 nephrectomy mice models (B) The gene expression levels of differentiation markers (PAX2, SIX2, and HOXB7) at 2 and 8 weeks after implantations (n = 3). (C) The fluorescence-based immunohistochemistry and quantitative analysis of AQP-1 expression for Native, PMEZ, PMEZ/dEV, PMEZ/IM, and PMEZ/dEV/IM implantations at 8 weeks. (D) The fluorescence-based immunohistochemistry and quantitative analysis of Nephrin expression of Native, PMEZ, PMEZ/dEV, PMEZ/IM, and PMEZ/dEV/IM implantations at 8 weeks. Scale bars equal to 100 μm (Values are presented as mean ± SD (n = 3) and statistical significance was obtained with unpaired t tests or one-way analysis of variance (ANOVA) with Tukey’s multiple comparison post-test (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001))

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Biomaterials Research

ISSN: 2055-7124

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