Recent advances in extracellular vesicle engineering and its applications to regenerative medicine

Biomaterials Research

Table 4 Cell preconditioning with non-inflammation related factors for EV engineering

No.	Target cell	Treatment material	Concentration	Ref.
1	RAW 264.7	Gemfibrozil	100 μg/ml	[77]
2	RAW 264.7	Silibinin	50 μg/ml	[78]
3	RAW 264.7	Edaravone	87.5 μg/ml	[79]
4	SMC	Cystatin C	1.95 μg/ml	[80]
5	Dendritic cell	Hemin	4.89 μg/ml	[81]
6	Primary microglia and neurons	Resveratrol	9.13 μg/ml	[17]
7	BMSC	TGFβ3	50 ng/ml	[15]
8	BMSC	Erythropoietin (EPO)	0.84 μg/ml	[82]
9	BMSC	tauroursodeoxycholic acid (TUDCA)	1.3 mg/ml	[95]
10	BMSC	Dimethyloxaloylglycine (DMOG)	0.17 mg/ml	[96]
11	UCMSC	Tanshinone IIA	2.94 μg/ml	[85]
12	UCMSC	Melatonin	4.65 μg/ml	[16]
13	ADMSC	Melatonin	4.65 μg/ml	[87]
14	ADMSC	Melatonin	2.32 ng/ml	[90]
15	ADMSC	Selenium	5 ng/ml	[91]
16	ADMSC	Curcumin	3.68 μg/ml	[18]
17	ADMSC	Ac4ManNAz	8.61 μg/ml	[92]

ISSN: 2055-7124