Recent advances in extracellular vesicle engineering and its applications to regenerative medicine

Biomaterials Research

Table 2 Gene editing for EV engineering

No.	Engineered materials	Method	Targeting cell	Ref.
1	PDGFR-RVG, hnRNPA2B1expressed/mirSilencer	lentivirus	HEK293T	[51]
2	RVG/BDNF	lentivirus	HEK293T	[52]
3	SERPINA5 protein	lentivirus	HEK293	[57]
4	Serpin protein	lentivirus	HEK293	[58]
5	miR-146a	lentivirus	PMSC	[56]
6	miR-214-3p	lentivirus	UCMSC	[55]
7	miR-133-3p	lentivirus	UCMSC	[54]
8	Tat protein	Lipofectamine	HEK293T	[59]
9	Ldlr mRNA	Lipofectamine	HEK293T	[60]
10	Protein drug (srIkB)	Effectene Transfection Reagent	HEK293T	[61]
11	Protein drug (srIkB)	Effectene Transfection Reagent	HEK293T	[62]
12	Protein drug (srIkB)	Effectene Transfection Reagent	HEK293T	[63]

ISSN: 2055-7124