Fig. 8

p53-suppressive tumor progression increased by miR-151a-3p overexpression in the HCC xenograft model. Acceleration of tumor growth by miR-151a-3p overexpression in a subcutaneous xenograft model (N = 5) (A-C). Representative images at day 18 post-transplantation of a subcutaneous xenograft nude mouse model injected with miR 151a-3p/miR-NC. Scale bar, 20 mm (A). In the HCC subcutaneous xenograft model, miR-151a-3p, miR-NC, and in vivo jet-PEI complex were injected thrice every three days from the third day after tumor transplantation, and the size of the tumors of each group was measured every three days (B). After the mice were sacrificed on the 18th day, the tumor was separated and the size was compared, and the weight of the tumors of each group was measured and plotted (C). The expression of the related target protein and downstream proteins in tumor tissues was analyzed by western blot (D, E). Data are shown as mean ± SEM. *P < 0.05 vs. miR-NC by Student’s t-test