Fig. 5
From: Tumor-derived systems as novel biomedical tools—turning the enemy into an ally
A Targeted therapy of multiple myeloma based on bone marrow homing. Subfigure (i) shows a schematic of cell membrane-coated polymeric nanoparticles for the treatment of multiple myeloma. Subfigure (ii) shows the ex vivo fluorescence imaging of the femur tissues at 48 h postinjection of DiR-loaded MPCEC nanoparticles in a 5 T multiple myeloma murine model. Adapted with permission from [68], (Copyright Wiley–VCH, 2022). B Genetically engineered antibody-anchored tumor cell membrane as nanovaccines. Subfigure (i) shows a schematic illustration of the design of the nano-AAM/CD40 and nano-AAM/CD40/lysate. Subfigure (ii) shows the flow cytometry analysis of in vitro DC maturation following different treatments. Subfigure (iii) represents ELISA analysis of IL-12p70 production by DCs without and with treatments. Figure (iv) represents the mean tumor growth curve of MC38 tumors in mice after different treatments. Here, p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Adapted with permission from [69], (Copyright Wiley–VCH, 2023)