Fig. 3
From: Tumor-derived systems as novel biomedical tools—turning the enemy into an ally
Assessment of cell membrane coating integrity and its impact on the internalization mechanism. In subfigure (i), TEM images are presented for various nanoparticle cores (Fe3O4, ZIF-8, Au, PLGA, and porous silicon) before and after cell membrane coating, accompanied by quantification of the ratio of complete cell membrane coating (Scale bar: 100 nm). Subfigure (ii) displays the distribution of cell membrane coating degrees on a SiO2 core, determined from TEM images (n = 325). The inset provides information on the proportion of SiO2 cores with a low cell membrane coating degree, specifically below 50%. In subfigure (iii), a schematic illustration is presented, elucidating potential endocytic entry mechanisms for partially coated cores. Adapted with permission from [57] (Copyright Springer Nature, 2021)