Fig. 16
From: Tumor-derived systems as novel biomedical tools—turning the enemy into an ally
Key considerations for clinical translation of tumor-derived systems. The initial steps involve optimizing the manufacturing process and implementing stringent quality control protocols to ensure the reproducibility, scalability, and consistency of the systems. Prior to clinical translation, rigorous evaluation of safety and toxicological profiles must be conducted in preclinical stages, addressing any potential risks associated with their use. Subsequently, the efficacy of the tumor-derived systems needs to be demonstrated through well-designed clinical trials, providing robust evidence of their therapeutic potential. Obtaining regulatory approval from relevant authorities is essential for ensuring compliance with safety and efficacy standards. Additionally, addressing any intellectual property and patent-related concerns is critical to establishing ownership, encouraging innovation, and supporting commercialization efforts