Fig. 7

Knockdown of Sema3A enhances laminin expression and improves motor function recovery after SCI (A) Immunofluorescence analysis in composite tiled scans of transverse sections stained for AS (anti-GFAP, Red) and laminin (anti-laminin, White). (B) Quantitative analyses of the laminin percentage in the LC. Results are the mean ± SEM; ^***p < 0.001. one-way ANOVA with Tukey post hoc test. (C) Comparison of BBB locomotor scores in the SCI, SCI + NSC, and SCI + NSC + siRNA-Sema3A group. ^# denotes a significant difference between the SCI group and the SCI + NSC group. ^* denotes a significant difference between the SCI group and the SCI + NSC + siRNA-Sema3A group. ^$ denotes a significant difference between the SCI + NSC group and the SCI + NSC + siRNA-Sema3A group. Results are the mean ± SD; ^#p < 0.05, ^$p < 0.05, ^$$p < 0.01, ^$$$p < 0.001, and ^***p < 0.001. Unpaired two-tailed Student’s t-tests