Fig. 12

Wound dressings with scar management function. A Silk fibroin/gelatin (SF/GT) electrospun nanofibrous dressings loaded with astragaloside IV (AS) were created to stimulate wound closure, increase angiogenesis, regulate newly formed kinds of collagen, and improve collagen organization in burn wounds. Reprinted with permission from ref [166]. Copyright 2015 Elsevier. B Scheme of PDT with spear and shear, fully armed, for topical deep hypertrophic scar therapy. (a) Dissolving microneedles (MN) based on HAase penetrated the stratum corneum and delivered medicines into hypertrophic scar lesions; (b) By attacking the ECM, HAase-based MN worked as a spear to carry more ALA into deep lesions, enhancing the efficiency of PDT; (c) For increased PDT, Met was used as a shear to impede the self-survival autophagic process. Reprinted with permission from ref [72]. Copyright 2022 Elsevier