| GLP-1A-Cys | GLP-1A-Cys | mD-G1A | bD-G1A | tD-G1A |
---|---|---|---|---|---|
Administration route | IV | PO | PO | PO | PO |
Dose (μg/kg) | 10 | 100 | 100 | 100 | 100 |
Tmax (h) | Â | 2.0 | 0.5 | 1.5 | 0.5 |
Cmax (ng/mL) |  | 0.56 ± 0.08 | 5.01 ± 2.37 | 7.63 ± 0.90 | 13.39 ± 5.54 |
AUC0-last (ng·h/mL) | 17.38 ± 0.70 | 2.88 ± 0.21 | 13.27 ± 0.91 | 24.43 ± 4.97 | 22.14 ± 2.03 |
MRT (h) | 11.2 ± 1.7 | 27.3 ± 22.8 | 7.6 ± 3.8 | 7.9 ± 1.3 | 6.6 ± 2.6 |
BA (%) | 100 | 1.0 ± 0.1 | 4.7 ± 0.3 | 8.6 ± 1.7 | 7.6 ± 0.7 |