Fig. 6

A Schematic illustration of metabolically engineered exosomes and mechanism regulating the macrophages in rheumatoid arthritis microenvironment (RAM). B Confocal microscopy images of macrophage polarization by DS-EXO. C Co-localization images of SR-A and EXOs in the inflamed joints of CIA mice. D Ex vivo organ images post-intravenous administration of the bare EXOs and DS-EXOs. E Clinical score of CIA mice with intravenous injection of the samples [122]. Reproduced with permission, Copyright 2021, The Author(s), Distributed under a CC-BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/), Published by American Association for the Advancement of Science