From: Current aspects of small extracellular vesicles in pain process and relief
Published year | Model | Resources | Effects | Modified methods | Ref. |
---|---|---|---|---|---|
2022 | Carrageenan-induced pain | M0 macrophages | Resolve inflammatory pain | Artificial vesicles from cells | [21] |
2021 | IVD | NPs | Anti-catabolic and anti-inflammation | Loaded with FOXF1 by electroporation | [115] |
2021 | DPN | MSCs | Normalized nerve conduction velocity and compound muscle action potential | Hybrid (fusion of EVs and PpyNps-liposome by freeze-thawing) | [149] |
2021 | IR-induced pain | Neurons | Attenuated pain hypersensitivity | Hypoxia-precondition induced high level of miR-126-3p | [56] |
2021 | SNI | Neurons | Reduced neuropathic hypersensitivity | Loaded with miR-21 antagomir | [54] |
2020 | CFA | M2 macrophages | Increased mechanical allodynia threshold | Transfection with lentivirus-miR-23a-3p | [97] |
2020 | SNL | MSCs | Upregulated withdrawal threshold and latency | Combination with alginate scaffold | [172] |
2017 | SNI | Neurons | Attenuated neuropathic hypersensitivity | Loaded with miR-23a antagomir | [53] |