From: Current aspects of small extracellular vesicles in pain process and relief
Published year | Condition | sEV type | Mechanisms | Effects | Ref. |
---|---|---|---|---|---|
2022 | Carrageenan-induced pain | CD200R+ macrophage-derived sEVs | CD200R+ sEVs transferred mitochondria to neurons in DRG | Resolved transient inflammatory pain | [21] |
2021 | CIBP | Cancer cell-derivd sEVs | Increased let-7d-5p in sEVs inhibited OPRM1 in DRG | Induced bone pain | [111] |
2017, 2021 | DRG neuron culture | NDEVs | TRPV1 activation promoted the release of miR-21-5p and miR-23a in NDEVs | Activated M1 macrophages | |
2020 | SNI | Serum-derived sEVs | Increased serum sEVs contained C5a and ICAM-1 | / | [101] |
2020 | Metastatic cancer pain | Cancer cell-derivd sEVs | Increased gene expressions in sEVs | Induced mechanical allodynia and thermal hyperalgesia | [106] |
2017 | Lumbar disc herniation | NPs | Increased miR-223 in NPEVs at the acute phase | Attenuated the neuronal activity in the pain pathways | [114] |
2017 | CFA | Endosomes | Activated NK1R and CLR on endosomes | Promoted pain transmission | |
2016 | SNL | MDEVs | Increased MDEV-IL-1β in CSF and spinal cord | Reduced PWT and PWL | [59] |