Fig. 4
From: Emerging nano-scale delivery systems for the treatment of osteoporosis
PU-ASP8-modified polyurethane nanomicelles targeting OCs. ASP8 has a higher affinity towards crystallized hydroxyapatite surfaces (resorbed bone surface). After the PU-ASP8 reaches the bone microenvironment, it undergoes cellular uptake by OCs, leading to an 80% reduction in the expression of miR-214. This substantial decrease in miR-214 levels plays a crucial role in improving bone health by promoting an increase in bone mass and a simultaneous decrease in trabecular space. PU-polyurethane; ASP8-eight repeating sequences of aspartate; OC- osteoclast