Fig. 2

Effect of CUR-CGNPs on OC. (A) β-cyclodextrin-conjugated GNPs with curcumin inhibits the osteoclastic differentiation of bone-derived macrophages. (B) Immunofluorescence analysis of bone-derived macrophages incubated in osteoclastic differentiation medium with CUR, CGNPs, or CUR-CGNPs for F-actin expression (RANKL-induced actin-ring formation). GNP: Gold nanoparticles; BMSCs: Bone marrow derived mesenchymal stem cells; CUR: Curcumin; CGNPs: β-cyclodextrin-conjugated GNPs; CUR-CGNPs: Curcumin loaded β-cyclodextrin-conjugated GNPs; RANKL: Receptor activator of nuclear factor κB. (B) is reprinted (adapted) with permission from Heo, D.N., Ko, W.K., Moon, H.J., Kim, H.J., Lee, S.J., Lee, J.B., Bae, M.S., Yi, J.K., Hwang, Y.S., Bang, J.B., and Kim, E.C., 2014. Inhibition of osteoclast differentiation by gold nanoparticles functionalized with cyclodextrin curcumin complexes. ACS nano, 8(12), pp. 12,049–12,062. Copyright 2014 American Chemical Society