Fig. 6

The novel drug nanobox-decorated biphasic hydrogel (named BRH-CRH) induced site-specific differentiation of MSCs into chondrocytes and osteoblasts by controllable phase/site-specific releasing kartogenin and melatonin. A Schematic Illustration of the Bilayered Scaffold-Loaded with KGN and BMP-2-Derived Peptides for Osteochondral Repair. B Cartilage relative protein expressions within BMSCs cultured on GSO hydrogels and GSO-KGN hydrogels for 21 days. C Bone relative protein expressions within BMSCs cultured on NF scaffolds and NF-P24 scaffolds for 21 days. D Macro-photographs of rabbit osteochondral defects after implanted with the control group, the pristine-bilayered scaffold group, and the DF-bilayered scaffold group for 4 and 12 weeks. E H&E and Masson staining images of samples after implantation for 4 and 12 weeks (scale bar = 1 mm). Copyright 2019, ACS publications