Fig. 5
From: Multifunctional hydrogels: advanced therapeutic tools for osteochondral regeneration
The photocurable hydrogels with TGF-β3-loaded methacrylated silk fibroin sealant promoted chondrocyte migration and differentiation. A Schematic illustration of the integral bi-layer silk scaffold combined with Sil-MA hydrogel in osteochondral repair through cytokines delivery and promoting of chondrocyte migration and differentiation. B Surgical procedures for the use of bilayer silk scaffolds combined with Sil-MA hydrogel in osteochondral repair. C Immediate implantation conditions at 0 weeks and repair conditions at 3 weeks were observed to evaluate the effect of the Sil-MA hydrogel. D Gross images, Micro-CT 3D images, and safranin-O/fast-green staining of different groups indicate lateral integration between neocartilage and adjacent cartilage. Copyright 2021, Elsevier