Fig. 2
From: Multifunctional hydrogels: advanced therapeutic tools for osteochondral regeneration
Injectable stem cell-laden gelatin HGM supramolecular hydrogels used in Osteochondral Regeneration. A Schematic illustration of the chondrogenic small molecules, growth factors, and encapsulation of MSCs in the injectable gelatin HGM supramolecular hydrogels. B The injection of pre-formed gelatin HGM supramolecular hydrogels to adhere to the cartilage defect. C The viability of hBMSCs in pre-formed gelatin HGM supramolecular hydrogels after injection via a G18 needle superimposed image of both calcein-AM (green, live) and ethidium bromide (red, dead) staining. Scale bar: 100 μm. D Macroscopic appearance of the rat knee osteochondral defect either treated with PBS or repaired by using the hydrogels loaded with chondrogenic agents at week 6 after surgery. E Cartilage regeneration evaluated by the Wakitani scoring system at week 6 after surgery. ∗  ∗  ∗ P < 0.001 vs. (GelMA with KGN); ˄˄˄P < 0.001 vs. (GelMA with TGF-β1). Copyright 2019, Elsevier