Fig. 1

3D-Printed Biodegradable High-Strength Supramolecular Polymer Reinforced-Gelatin Hydrogel Scaffolds used in Osteochondral Regeneration. A The compositions of bioink A and bioink B, and 3D-bioprinting method of the biohybrid gradient scaffolds assisted with a low-temperature receiver. B Formation of stable hydrogel scaffold after UV light-initiated polymerization and main hydrogen bonding interactions in the PACG-GelMA network; (C) The repair of osteochondral defects treated with the biohybrid gradient PACG-GelMA hydrogel scaffold with Mn2 + and BG being respectively loaded on the top layers and bottom layers in animal experiment. D Compressive stress–strain curves of the printed hydrogel scaffolds; (E) Cyclic compressive stress–strain curves for the printed gradient scaffold. The cycle numbers were set as 100. F Characteristic 3D reconstruction images of micro-CT analysis of the repaired subchondral bone at 4, 8, and 12 weeks in different groups. G HE, toluidine blue (T-B) staining, and immune histological staining for Coll II, GAGs, COL I, and OCN. Copyright 2019, Wiley