Fig. 5
From: Exosomes derived from mir-214-3p overexpressing mesenchymal stem cells promote myocardial repair
miR-214OE-Exo promoted angiogenesis and cardiomyocyte survival in infarcted hearts. (A) Neovascularization at the border zone 28 days after MI was evaluated by staining with CD31 (red) and nuclei (blue). Scale bar = 50 μm. (B) α-SMA positively stained arterioles at the border zone 4 weeks after MI. Scale bar = 50 μm. (C) Representative images showing the terminal deoxynucleotidyl transferase-mediated dUTP nick end‐labeling (TUNEL) positive cells in the heart tissue among the different groups. Scale bar = 50 μm. (D) Cleaved Caspase-3 staining at the border zone 28 days post MI. Scale bar = 50 μm. (E and F) Quantitative analysis of the CD31(E) and α-SMA(F) density in the heart tissue of rats from the different groups. (n = 5 animals for each group). (G) Quantitative analysis of the apoptotic rates among the different groups. (n = 5 animals for each group). (H) Quantitative analysis of cleaved-caspase-3+ cells at the border zone among the different groups. (n = 5 animals for each group)