Fig. 4
From: Exosomes derived from mir-214-3p overexpressing mesenchymal stem cells promote myocardial repair
miR-214OE-Exo effectively preserved cardiac function in rats with MI in vivo. (A) Representative images of M-mode echocardiography captured 28 days after MI between different groups. (B) The representative Masson’s trichrome-stained myocardial cross-Sect. 4 weeks after MI with the injection of PBS, Ctrl-Exo, and miR-214OE-Exo. Red frame indicates the infarct zone and yellow frame indicates the border zone. Scale bar = 20 μm. (C) HE staining at the border zone 28 days post MI. (D-E) Left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) measured by echocardiography 28 days after MI. (n = 5 animals for each group). (F) Quantitative analysis of heart fibrosis between different groups. (n = 5 animals for each group)