Skip to main content
Fig. 9 | Biomaterials Research

Fig. 9

From: Oxygen-loaded microbubble-mediated sonoperfusion and oxygenation for neuroprotection after ischemic stroke reperfusion

Fig. 9

The biomechanism of OMB treatment for S/R injury prevention can be broadly separated into local O2 release and MB cavitation. The enhancement of endothelial shear stress activates eNOS for vasodilation, causing sonoperfusion. The effects of sonoperfusion and local O2 release promote cellular aerobic respiration, inhibiting HIF-1α expression, mitochondrial dysfunction, and subsequent apoptosis. The release of BDNF protects neurons, reducing inflammatory responses and BBB disruption to prevent S/R injury and protect neuron function

Back to article page

Biomaterials Research

ISSN: 2055-7124

Contact us