Fig. 8

Ratios of protein and mRNA expression within the S/R cerebral hemispheres relative to the normal cerebral hemispheres after OMB treatment for 3 days. A-C The protein expression levels of eNOS, BDNF, and NF-κB reveal the activation of vasodilation, neuron growth, and inflammatory response, respectively. N = 5/group. D-H The mRNA expression levels of HIF-1α, IL-1β, MMP-9, BCL2, and IL-10 indicate hypoxia, pro-inflammatory M1 microglia, BBB disruption, anti-apoptosis, and anti-inflammatory M2 microglia, respectively. N = 5–9/group. The plus ( +) symbol represents US sonication. Significant differences are indicated: *p < 0.05, **p < 0.01, ***p < 0.001, one-way ANOVA with Bonferroni's multiple comparisons test