Fig. 4

Biosafety of BBB opening induced by OMB cavitation. A The leakage of Evans blue dye within the murine S/R brains reveals the regions of BBB opening. The white arrows indicate brain hemorrhage. B, C In vitro detection of (B) SCD and (C) ICD of OMBs under different acoustic pressures. N = 3/group. Significant differences are indicated: *p < 0.05, **p < 0.01, by one-way ANOVA with Bonferroni's multiple comparisons test