Fig. 2From: Trends in mechanobiology guided tissue engineering and tools to study cell-substrate interactions: a brief reviewRepresentative model of substrate mediated osteogenic differentiation wherein substrate stiffness (mechanical signal) activates mechanotransduction pathway involving YAP/TAZ (1Â A-1B) and non-mechanical signals from substrate leads to osteogenesis via canonical BMPR signaling pathway (2). Adapted with permission from [68]Back to article page