From: Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)
Pathway | Adaptor | Key sequences | POI | POI ligands | Refs |
---|---|---|---|---|---|
Proteasome | VHL | MLAP(OH)YIPM | METAP2 ER | Fumagillo Estradiol | [60] |
 | LAP(OH)YI | AR ER CREPT | Dihydrotestosterone Estradiol VRALKQKYEELKKEKESLVDK | ||
 | ALAPYIP | Akt FRS2α PI3K Tau | Recognition peptide for Akt2 (P-ser474) IENPQYFSDA GPGGDYAAMGACPASEQGYEEMRA YQYQDATADEQG | ||
 | β-TRCP | DRHDS(P)GLDS(P)M | METAP2 | Ovalicin | [11] |
 | KEAP1 | LDPETGEYL | Tau | YQYQDATADEQG | [118] |
 | / | RRRG | α-synuclein | GVLYVGSKTR | [136] |
Lysosome | / / / | KFERQKILDQRFFE MDFSGLSLIKLKKQ cyclic RGDyK | DAPK1 α-synuclein PD-L1 PD-L1 | A fragment of the GluN2B subunit A short peptide of β-synuclein DKEMAATSAAIEDAVRRIEDMMNQ BMS-8 | [24] [131] [132] |