Fig. 5

A Subcutaneous implantation of bionanomatrix coated silicone implants into the mouse model for a month. B Histological analysis of tissues surrounding the implants. Scale bar of left H&E image: 1,000 μm. Scale bar of right H&E image: 100 μm. C Analysis of capsule thickness surrounding the implants evaluated by H&E and Masson’s trichrome staining. Scale bar: 100 μm. D Quantification of capsule thickness for each group. ****p < 0.0001 between two groups. E Evaluation of α-SMA positive cells in the capsules by IHC analysis. Scale bar: 100 μm. F Quantification of α-SMA positive cells for each group. **p < 0.01, ***p < 0.001 between two groups. Sham: no implantation (negative control), Cont: Uncoated silicone, NO-30: 30 layers of bionanomatrix coated silicone, and NO-60: 60 layers of bionanomatrix coated silicone