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Fig. 4 | Biomaterials Research

Fig. 4

From: Stabilization and improved functionality of three-dimensional perfusable microvascular networks in microfluidic devices under macromolecular crowding

Fig. 4

MMC promotes the formation of cell-cell junctions. (A) Representative maximum intensity projections of confocal z-stacks taken of MVNs grown under control or crowded (+ MMC) conditions and stained for DAPI and with phalloidin for F-Actin, as well as immunostained for adherens junction proteins, VE-Cadherin and β-catenin. Scale bar = 50 μm. (B) Western blot and densitometric band analysis of VE-cadherin and β-catenin normalized to the respective GAPDH levels of samples collected on days 4 and day 7. Protein levels are displayed as fold-changes as compared to control. *, p < 0.05; ***, p < 0.001. n = 4 biological replicates

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Biomaterials Research

ISSN: 2055-7124

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