Fig. 3
From: Responsive manganese-based nanoplatform amplifying cGAS-STING activation for immunotherapy
GSH-dependent MPCZ NPs decomposition and Mn2+, ZPP release behaviors. Temperature elevation curves (A) and infrared thermal images (B) of H2O and MPCZ (comparable to 100 and 200 µg/mL MPC or 5.0 and 10.0 µg/mL ZPP) suspension under 808 nm laser irradiation (1 W/cm2, 10 min). (C) Image of MPCZ solution with or without NIR irradiation, the red arrow points to gas bubbles. (D) UV − vis spectra of GSH reaction with different concentrations of MPCZ NPs and (E) corresponding percent depletion of GSH with NIR irradiation (1 W/cm2, 10 min). Percentages of released Mn2+ (F) and ZPP (G) from MPCZ NPs over time with presence or absence of GSH and NIR laser irradiation. UV-vis absorption spectra of MB following Fenton-like reaction-mediated degradation by Mn2+ (H) and GSH-treated MPCZ NPs (I) under 808 nm laser irradiation (1 W/cm2, 10 min)