Fig. 6

Future prospects of biomaterial-based MSC generation from PSCs. MSCs can be generated from iPSCs with the help of various biomimicking materials. Several natural and synthetic materials can induce the efficient growth and differentiation of MSCs. Functionalization of these materials through the conjugation of select MSC-inducing growth factors, exosomes, and modifications by varying stiffness and topology represent promising improvements to effectively and efficiently differentiate PSCs into MSCs.