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Fig. 6 | Biomaterials Research

Fig. 6

From: Regenerated silk fibroin based on small aperture scaffolds and marginal sealing hydrogel for osteochondral defect repair

Fig. 6

mRNA-seq and Western blot analysis: a Top 20 most enriched scatterplots and bar plot in KEGG analysis, with the p-value of 0.01 (red) and 0.05 (blue) highlighted to indicate the significance of the results based on genome background enrichment; b Heat map of differentially expressed genes between Group E and the control for 4.5 months in vivo; c Protein levels of collagen II, aggrecan, P-AKT, and P-MAPK in C28/I2 and human mesenchymal stem cells cultured with different groups were determined by Western blot after seven days in vivo; d Relative expression analysis of Western blot with ImageJ. * represents p < 0.05, ** represents p < 0.01, *** represents p < 0.001, and **** represents p < 0.0001

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