Fig. 5

Schematic diagram of manganese based biomaterials for tumor immunotherapy. A Schematic illustration of the design and function of AuNC@MnO2 (AM). B Oxygen-boosted immunogenic PDT induced antitumor immune response and tumor regression. (a) Tumor growth curves. (b) Mice weight of lung metastasis experiment. (c) The number of metastatic lesions counted from excised lungs. (d) Experimental illustration of anti-metastasis from local PDT. (e) Histological examination of the metastatic nodules in the lung tissue sections. (f) Representative immunofluorescence images of tumor sections stained with specific antibodies against CRT. (g) The expressions of CD86 and CD83 on DCs in tumors at 48 h after treatment. (h-i) The percentage of activated CD8 T cells, CD4 T cells and NK cells in tumors (h) and TDLNs (i) analyzed with flow cytometry at 48 h after treatment. (Reproduced with permission from [78] Copyright © 2017, Elsevier)