Scheme 1

The development and characteristics of DSeP@PB for the treatment of diabetic wounds. The hydrogels were fabricated via reinforcement of diselenide-containing polyethylene glycol (PEG) hydrogels synthesized by ring-opening of γ-selenobutylacetone by polydopamine nanoparticles (PDANPs) and Prussian blue nanozymes in a one-pot low-cost green approach. Owing to the chemical double cross-linking mechanisms (diselenide and selenide bonds), DSeP@PB possesses distinct properties, such as on-demand degradability, photocontrolled release, injectability, self-healing and bioadhesion, realizing enhanced efficacy (antioxidant functions, anti-inflammatory functions and antibacterial activity) to promote diabetic wound healing by increased angiogenesis, collagen deposition, and inflammation inhibition