Fig. 14
From: Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery
Design of doxorubicin-loaded, aptamer-decorated nanogels through multiple streptavidin–biotin interactions by the simultaneous assembly of B-DNA, streptavidin, A-DNA, and doxorubicin. Diffusion of doxorubicin-loaded nanogels inside the cell through receptor-mediated endocytosis and delivery of doxorubicin and apoptosis are depicted. Chemical structures of the biotin derivative, doxorubicin, and streptavidin are also given (left bottom corner). Reproduced with permission from Thelu et al. [134]. Copyright American Chemical Society (2019)