Table 2 Blockade and depletion of Tregs with antibodies and nanoparticles

Tregs blockade

Anti-GITR and anti-PD-1

-

in vivo

intratumoral injection

GITR and PD-1

[68]

Anti-PD-1, anti-PD-L1 and anti-CTLA-4

-

in vitro

-

PD-1 and CTLA-4

[59, 64, 65, 67]

Tregs depletion

Anti-CTLA-4

Iron nanoparticles

in vivo

mediated

Photothermal therapy

intravenous injection

CTLA-4

[77]

Anti-CD25 and anti-CCR4

-

in vitro

-

CD25 and CCR4

[72]

Daclizumab and cyclophosphamide (anti-CD25)

-

in vivo

intravenous injection

CD25

[67, 73]

Anti-CD36

-

in vitro, ex vivo

-

CD36 and PPAR-β

[62, 80]