Fig. 7
From: Reprogramming the tumor microenvironment with biotechnology
Reprogramming T cell exhaustion with combination therapeutic strategies can increase efficacy. a Efficacy of a single PD-1 blockade and combined blockade of PD-1 and CTLA-4 on the production of effector cytokines from CD8.+ TILs. (Reproduced with permission from [92] Copyright 2021, Frontiers in Immunology). b Blocking the Tim-3 and PD-1 signaling pathways restores IFN-γ production. (Reproduced with permission from [89] Copyright 2021, Frontiers in Immunology)