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Fig. 7 | Biomaterials Research

Fig. 7

From: Verapamil-loaded supramolecular hydrogel patch attenuates metabolic dysfunction-associated fatty liver disease via restoration of autophagic clearance of aggregated proteins and inhibition of NLRP3

Fig. 7

Vera@CLCMP patches reverse diet-induced obesity and hepatic steatosis. A-L C57BL/6 male mice kept on HFD for 9 weeks had Vera@CLCMP or CLCMP patches applied to the dorsal skin. LFD-fed mice of the same age were used as a negative control. A Body weight of mice fed a HFD and treated with Vera@CLCMP or CLCMP patches. B Food intake during treatment period. C Gross liver morphology and D total liver mass of mice in each group indicated. E-G Serum ALT, AST, and ALP levels. H H&E staining (upper) and Oil-Red O staining (lower) of liver sections from mice in each group indicated. Scale bar, 100 μm. I Histological MAFLD activity score (NAS). J Oil-Red O-stained area was quantified. K H&E staining of epididymal white adipose tissue from mice in each group indicated. Scale bar, 100 μm. L Average adipocyte area of epididymal white adipose tissue was quantified. Data is shown as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001 (One-way ANOVA, followed by Tukey’s test)

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Biomaterials Research

ISSN: 2055-7124

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