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Scheme 2 | Biomaterials Research

Scheme 2

From: Periosteum-inspired in situ CaP generated nanocomposite hydrogels with strong bone adhesion and superior stretchability for accelerated distraction osteogenesis

Scheme 2

Illustration of the cellular and molecular mechanism of PEGS/ICPN hydrogels for promoting DO process. The introduction of in situ self-assembled CaP nanoparticles to PEGS hydrogel enables spontaneous recruitment of endogenous stem cells and promotes cell adhesion through the FAK pathway. This nano-composite hydrogel also creates a favorable immune microenvironment to promoting bone formation and neovascularization. Eventually, PEGS/ICPN hydrogels promote new bone formation and mineralization during DO through synergistic effects of angiogenesis and osteogenesis

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Biomaterials Research

ISSN: 2055-7124

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