Skip to main content
Fig. 5 | Biomaterials Research

Fig. 5

From: Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody

Fig. 5

Rg3-PNPs@PPP and DOX combination promoted ICD effect and DC maturation in mice bearing 4T1 tumor. (A) Schedules for the indicated treatment. p.t. means peritumoral. (B) Immunohistochemistry of CRT and HMGB1 expression in tumors. (C) Immunofluorescence dual-staining of CD11 (red) and CD86 (green) in tumors sections. (D) Populations of CD80+, CD86+ and MHCII+ cells (matured dendritic cells markers), gated on CD11c+ DC cells in tumor-draining lymph nodes by flow cytometry. Data are presented as the mean ± SD (n = 3). 1. PBS; 2. Rg3@PPP; 3. DOX@PPP; 4. Rg3+DOX@PPP; 5. Rg3-NPs+DOX@PPP; 6. Rg3-PNPs+DOX@PPP. *p < 0.05, **p < 0.01 vs the PBS group

Back to article page

Biomaterials Research

ISSN: 2055-7124

Contact us