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Fig. 4 | Biomaterials Research

Fig. 4

From: Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody

Fig. 4

Tumor spheres penetration and mitochondrial co-localization of hydrogels in 4T1 cells. Representative images of uptake and penetration of (A) CUR-PNPs and (B) CUR-PNPs@PPP in tumor spheres. Quantitative analysis of the mean fluorescence intensity of (C) CUR-PNPs and (D) CUR-PNPs@PPP. Data represented as mean ± SD from at least 3 spheroids per condition. *p < 0.05 and **p < 0.01 vs. CUR, #p < 0.05 vs. CUR-NPs. Co-localization of (E) CUR-PNPs and (F) CUR-PNPs@PPP into the mitochondria of 4T1 cells after 2 h incubation. Orange spots in the merged images denoted the co-localization within the mitochondria. Red: Mitotracker red. Green: CUR

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Biomaterials Research

ISSN: 2055-7124

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