Fig. 6

Optical imaging and Anti-tumor activity of PTK7-GEMs in xenotransplanted subcutaneous tumors. A Time-lapse fluorescence imaging at 0.5, 1, 2, 3, and 4 h after tail vein injection of Cy5-labeled PTK7-GEMs (right) or Lib-GEMs (left). The tumor site is indicated using a red circle. B Biodistribution of PTK7-GEMs-cy5 or Lib-GEMs-cy5 in the major viscera and tumors at 4 h after injection. C Growth curve of the tumors during therapy. In vivo evaluation of antitumor effects in the 5637 xenografted bladder cancer mouse model (n = 6 mice per group, n = 6 groups). D The tumor weights from the different groups are shown as a scattergram. E Images of tumor tissues from mice sacrificed at 32 days post inoculation. F Body weight changes during therapy. Data represents the mean ± SEM, n = 6; NS = not significant. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001