Fig. 7
Gasotransmitters combined with magnetothermal/photothermal therapies for biofilm eradication and tissue remodeling. A Schematic illustration of magneto-based synergetic therapy for the eradication of bacterial biofilms. SEM images show that the synergistic therapy resulted in biofilm dispersion and morphology distortion of S. aureus (Control, MNP-SNO, MNP-SH + MH and MNP-SNO + MH, respectively). Reproduced with permission [104]. Copyright 2021, Wiley-VCH GmbH. B Antibacterial illustration of the “gas-sensitized hyperthermia” strategy. C Efficacy in the destruction of E. coli and MRSA biofilms using the “H2S-sensitized hyperthermia” strategy (Up: confocal microscopy images of biofilm staining; down: SEM images of biofilms). D Schematic illustration of H2S gas release reversing the proinflammatory microenvironment and promoting wound healing. (i) Immunofluorescent (TNF-α/IL-6, CD206/iNOS and CD31/α-SMA, respectively), immunohistochemical (CD31) and Masson’s staining demonstrating great tissue remodeling achieved by H2S therapy (Up: control; middle: MSG + NIR; down: MSG + NIR). Reproduced with permission [110]. Copyright 2022, American Association for the Advancement of Science