Fig. 6
From: CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin
Anti-tumor effect of E8-PE38 in a PDX model. a CDH17 expression in a gastric PDX tumor. Scale bars: 40 μm. b Schema of treatment schedule in the PDX model. c Tumor growth curves from the treated PDX model with PBS, 0.4 or 0.6 mg/kg E8-PE38 immunotoxin (n = 6-7, ****p < 0.0001, two-way ANOVA). Both of dosages significantly inhibited the tumor growth. Higher dose of immunotoxin showed better anti-tumor efficacy. d Individual tumor growth curves for all three groups in c. e Body weight of the treated mice in c. f Survival curves of PDX mice treated in c (n = 6-7, *p < 0.05, **p < 0.01, ***p < 0.001, Log-rank (Mantel-Cox) test)