The role of extracellular vesicles in osteoarthritis treatment via microenvironment regulation

Biomaterials Research

Table 4 miRNAs defined in EVs as a working biomolecule for OA therapy

EV Source	miRNA	Selected animals model in vivo	Role	Pathway	Effect	Reference
UMSCs	lncRNA H19	SD Rats	Promote chondrocyte migration and matrix secretion and inhibit cell apoptosis and senescence	miR-29b-3p/FOXO3	Promote sustained cartilage repair	[86]
AD-MSCs	miR-100-5p	C57BL/6 mice	Promote the proliferation of chondrocytes, increase the level of chondrocytes autophagy, enhance matrix synthesis, and reduce the expression of metabolic factors	mTOR signaling pathway	Protect articular cartilage from damage and ameliorate gait abnormality	[78]
S-MSCs	miR-140-5p	SD rats	Increase the proliferation and migration of chondrocytes	Wnt signaling pathway	Successfully prevent OA	[73]
S-MSCs	miR-155-5p	BALB/C mice	Promote the proliferation and migration of chondrocytes and inhibit cell apoptosis	Runx2	Prevent OA	[75]
hBM-MSCs	miR-136-5p	C57BL/6 mice	Promote the migration of chondrocytes and inhibit chondrocytes degeneration	Targets ELF3	Prevent traumatic OA	[150]
MSCs	miR-135b	SD rats	Promote chondrocyte proliferation and inhibit cartilage degradation	Sp1	Promote cartilage repair	[81]
hMSCs	miR-206	C57BL/6 mice	Promote chondrocyte proliferation and inhibit chondrocyte apoptosis	KLF3-AS1/miR-206/GIT1 axis	Attenuate chondrocyte injury	[19]

ISSN: 2055-7124