Table 1 Physicochemical properties of bone-targeted NIR fluorophores
From: P800SO3-PEG: a renal clearable bone-targeted fluorophore for theranostic imaging
Fluorophore | P800SO3-Cl | P800SO3 [29] | P800SO3-SH | P800SO3-PEG |
|---|---|---|---|---|
MW (Da) | 857.15 | 986.23 | 988.19 | 1,014.23 |
LogD, pH 7.4 | -4.80 | -7.03 | -7.04 | -8.65 |
TPSA (Ã…2) | 235.71 | 285.07 | 275.84 | 294.30 |
HBA/HBD | 13/4 | 16/4 | 15/4 | 17/4 |
Charges (+/-) | 1/4 | 1/5 | 1/5 | 1/5 |
Rotatable bonds | 13 | 18 | 17 | 23 |