Table 1 Distinct advantages and disadvantages of different collagen preparation methods [10], © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
Sources | Advantages | Disadvantages |
|---|---|---|
Tissue extracted collagen | High yield No antigenic p-determinant | Potential of disease transmission |
Cell synthesized collagen | Can be autologous | Low yield |
Recombinantly produced collagen | Low immune response | Low yield Stability issues |
Peptide synthesis produced collagen | Exclusion of allogeneic/xenogeneic issues | Low yield Assembly/registration issues |