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Table 1 Pharmacokinetic parameters after intravenous injection of free Doxo, Doxo-micelles, and Doxo-SPIO-micelles against mice at a dose of Doxo 2.5 mg/kg (n = 5, mean ± stdev)

From: Enhanced thermodynamic, pharmacokinetic and theranostic properties of polymeric micelles via hydrophobic core-clustering of superparamagnetic iron oxide nanoparticles

  Free Doxo Doxo-micelles Doxo-SPIO-micelles
AUC (μg·min/mL) 44.4 ± 4.6 908 ± 86 3310.6 ± 449.7
t1/2 (min) 2.1 ± 0.6 12.4 ± 0.6 50.5 ± 1.8
CL (mL/min/kg)* 56.2 ± 10.9 2.7 ± 0.2 0.76 ± 0.1
MRT (min)** 3.0 ± 0.8 17.9 ± 0.9 72.9 ± 2.6
Vss (mL) 172.9 ± 27.5 49.0 ± 7.3 55.4 ± 5.5
  1. * CL; drug clearance, ** MRT: mean residence time