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Table 1 Pharmacokinetic parameters after intravenous injection of free Doxo, Doxo-micelles, and Doxo-SPIO-micelles against mice at a dose of Doxo 2.5 mg/kg (n = 5, mean ± stdev)

From: Enhanced thermodynamic, pharmacokinetic and theranostic properties of polymeric micelles via hydrophobic core-clustering of superparamagnetic iron oxide nanoparticles

 

Free Doxo

Doxo-micelles

Doxo-SPIO-micelles

AUC (μg·min/mL)

44.4 ± 4.6

908 ± 86

3310.6 ± 449.7

t1/2 (min)

2.1 ± 0.6

12.4 ± 0.6

50.5 ± 1.8

CL (mL/min/kg)*

56.2 ± 10.9

2.7 ± 0.2

0.76 ± 0.1

MRT (min)**

3.0 ± 0.8

17.9 ± 0.9

72.9 ± 2.6

Vss (mL)

172.9 ± 27.5

49.0 ± 7.3

55.4 ± 5.5

  1. * CL; drug clearance, ** MRT: mean residence time
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Biomaterials Research

ISSN: 2055-7124

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